This research is concerned with explaining the variation in growth rates among employment subcenters. It aims to find answers to the question: What factors/variables contribute to the growth or decline of employment subcenters? More specifically, the study (1) identify, describe and classify employment subcenters in the Dallas-Fort Worth (DFW) metropolitan area, and (2) explain the variation in their growth rate and the change in their size over a specified period of time, through testing a set of variables extracted from related literature. Multiple regression analysis technique is employed to complete the empirical analysis. The DFW metropolitan area was chosen as a case study to explore the phenomena in similar polycentric regions. Data sets covering over six thousands Traffic Survey Zones (TSZ) in the Metroplex were used to identify subcenters. The results of the study identify several explanatory variables affect the growth rate of subcenters in the DFW metropolitan area. Distance to the DFW international airport, distance to the Dallas and Fort Worth traditional CBDs, Distance to the nearest subcenter, whether the area is served by public transportation or not, and the portion of subcenter's area located in floodplain zone were statistically significant in explaining the variation in the growth rate of employment subcenters in the area.