Abstract: The purpose of the study was to evaluate the 2002-2004 Nutrition and Fitness for Life/Childhood Overweight Advisory Committee for Health program, a community intervention and prevention program to improve the health of Latino families with overweight children. The 8-week program utilized culturally unique and relevant program components specifically tailored to Latino culture, characteristics, and perspectives. The program also integrated a multicomponent approach of nutrition education, behavioral health education, and physical activity education, which are considered best practices in the obesity program literature. Since the 1970s, childhood overweight rates have consistently increased, especially in Latino populations. Despite worsening health disparities, obesity research on the Latino population is small. Therefore the study serves as an addition to the body of Latino obesity literature by evaluating program outcomes at specific assessment periods: preprogram, immediately postprogram, 6 months postprogram, and 12 months postprogram. The primary outcome variable consisted of the body mass index (BMI) percentile, while secondary outcome variables included self-report data such as self-esteem, nutrition, and physical activity information. In an effort to further study long-term programmatic effects and challenges, an additional study was conducted utilizing a qualitative methodology and procedures with a subsample of program graduates who were successful and unsuccessful at weight loss. Results demonstrated a significant change in BMI percentile, nutrition, physical activity, and long-term self-esteem. The content analysis revealed three main themes in the successful group (increase in health knowledge and behavioral change, changes in healthy foods, and the integration of health into daily life) and three main themes in the unsuccessful group (changes in healthy foods, diabetes in the family, environmental and personal challenges to health). In further analyzing the data, an additional three main themes surfaced that both groups had in common (enjoyment of program activities and exercise, support from peers, and stressful life experiences). This study is an informative addition to research on Latino overweight children by outlining program outcomes as well as programmatic best practices and challenges, which are useful when developing future Latino childhood overweight programs.