Abstract: Although estimates of Catholic medical students (M.D. program) number about 19,000 in the United States and Puerto Rico, few campus ministry programs or other church-sponsored organizations provide formal opportunities for these students to integrate Catholic moral and spiritual values into clinical medical education. This dissertation focuses on three principle areas of research and inquiry. First, a foundation for campus-based ministry to medical students is considered to explore the special challenges of this type of pastoral outreach. Second, a 103 subject internet-based survey is presented and analyzed to understand the spiritual needs and concerns of a nationwide sample of medical students at both Catholic and non-Catholic medical schools. Finally, a project in ministry is outlined which describes the nature and challenges of ministry to medical students at a nationally recognized private non-sectarian medical school. The results of the nationwide sample indicate that a significant number of students are interested in receiving direct pastoral care during medical education as a means of reflecting on practical moral and spiritual questions about the faith in medical practice. In spite of the time constraints and pressures of medical education, surprising numbers of Roman Catholic students express the view that medical education has helped them to understand God's presence and creative power in their lives. Medical students are also interested in socializing and praying with other students, in part to address the personal spiritual deficit brought about by intensive academic and clinical work. The dissertation argues that university pastors and other chaplains must not defer formal contact with medical students, waiting until these students are licensed and practicing physicians. Instead, in cooperation with their respective bishop, pastors and other campus ministers should consider developing a more comprehensive and personal approach to the discussion of important ethical and spiritual themes which arise in the practice of medicine before the constraints of clinical education and medical practice crowd out time for this interchange and support.