Abstract: This was a single case study utilizing a resiliency-based Bowen (1978) Family Systems approach to the treatment of an adult sibling survivor of homicide with complicated grief. The resiliency-based piece of treatment was based on Wolin and Wolin's (1993) Challenge Model. The impact of horrific loss on a family system is incomprehensible. A focus on multigenerational patterns of strength, as well as patterns of maladaptation, scaffolds the client in a way that he/she does not feel doomed to repeat the intensity of dysfunction within many generations. This approach was addressed through a literature review for each of the key concepts, such as sibling bereavement, especially in relation to homicide, resilience in the individual and in the family system, Bowen Family Systems, complicated grief, and multigenerational transmission. The study identified how these concepts are interrelated and utilized in the treatment of this sibling survivor of homicide. Kübler-Ross's (1969) model is lacking with this particular population in that it places emphasis upon individual grieving reactions. Grief and loss cannot be understood apart from the context in which they occur. It is remarkable that there has been little or no systemic research that has focused on psychotherapy of bereavement after homicide. This single case study may pave the way for researchers to examine the efficacy of a broad, systemic treatment for this population. This case study of the client, a sibling survivor of homicide who had been in ongoing treatment with the author for almost 2 years, includes a background of the client, an assessment, and the course of her treatment, including early, intermediate and later stages. Excerpts from psychotherapy transcripts are provided as anecdotal illustration of the clinical approach. Letters written by the client and a timeline that she constructed are also included. A discussion of the case is presented, with implications for research, theory, and practice.