Abstract: A small sample of Caucasian women, age 32-46 with endometriosis participated in semi-structured interviews and were given measures (McGill Pain Questionnaire, Center for Epidemiology Studies Depression Scale, West Haven-Yale Multidimensional Pain Inventory, and Vanderbilt Multidimensional Pain Coping Inventory). Participants had 14-18 years of education and had been experiencing pain from endometriosis for 11-31 years. Their endometriosis went undiagnosed between 6-20 years. Participants experience, coping strategies, psychological meaning of having endometriosis were of interest. Thirty-five themes in 10 descriptive categories emerged from the qualitative data analysis. The results of the present study are important for the mental health clinician and physician to be aware of when treating women with this disease. The amount of severe life interference and the meaning of having endometriosis to the woman; how long the woman has gone without a correct diagnosis; the duration of having dealt with things like pain and infertility; the adequacy of their medical treatment; coping strategies, emotions, and social support are all important to psychological well-being and overall health. Chronic pain, severe bleeding, and infertility caused the most life interference and psychological distress for these women.