Abstract: An extensive body of epilepsy research documents the role of the left hippocampus in verbal episodic memory. This research indicates left temporal lobe epilepsy patients show pre-operative deficits in verbal episodic functioning and decline in verbal episodic memory following temporal lobectomy. Semantic memory has traditionally been associated with brain regions outside of the hippocampus, but recent studies have raised questions about the role of the hippocampus in semantic memories. The purpose of this study was to investigate the relationship between the hippocampal volume asymmetry and extra-hippocampal volume asymmetry and performance on formal measures of episodic and semantic memory. A 2 X 2 X 2 design was utilized to correlate the hippocampal volume asymmetry and extrahippocampal volume asymmetry to performance on semantic memory and episodic memory measures. Pre-surgical semantic and episodic memory performance and post-surgical change in semantic and episodic memory performance was measured. Segmentation of hippocampal and extra-hippocampal volume asymmetry was conducted using AFNI. The semantic memory variables used for the current study included WAIS-Vocabulary, WAIS-Information, and Boston Naming Test. The episodic memory variables used for the current study included WMS-Logical Memory (LM)-Immediate Recall, LM-Delayed Recall, Selective Reminding Test (SRT)-Long Term Storage, and SRT-Consistent Long Term Retrieval. The results of the study found that larger pre-surgical left extra-hippocampal volumes were correlated with greater post-surgical decline on BNT. There was no correlation between extra-hippocampal volume asymmetry and post-surgical change in Vocabulary or Information. The extra-hippocampal volume asymmetry was not correlated with post-surgical change on any of the episodic memory variables. The hippocampal volume asymmetry was not associated with post-surgical change in any of the semantic or episodic memory variables. There was no relationship between hippocampal volume asymmetry and pre-surgical episodic memory variables or semantic memory variables. There was also no relationship between extra-hippocampal volume asymmetry and pre-surgical semantic memory variables or pre-surgical episodic memory variables. Limitations of the current study and future directions are discussed.