Glycine supplementation to improve insulin sensitivity in humans

by Boni Epse Attobla, Marie-Hippolyte, M.S., THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, 2014, 70 pages; 1555104


The main purpose of this pilot study was to investigate the insulin sensitizing effect of glycine as a dietary supplement in insulin resistant (IR) normoglycemic subjects (N= 10), and to determine significant changes in insulin sensitivity and lipid profile after four weeks of glycine supplementation. Descriptive statistics were used to describe the basic characteristics of the study population. A paired t-test was used to determine differences between insulin sensitivity and lipid profile pre- and post- intervention, considering the estimation of HOMA-IR and Matsuda- index scores. Results showed that glycine supplementation might improve triglyceride (TG) levels in European Americans; and low-density lipoprotein cholesterol (LDL-c) concentrations in women after a four-week of intervention. Although, this work reports interesting results, these findings did not provide sufficient evidence to demonstrate that glycine supplementation may improve insulin sensitivity and lipid profile in insulin-resistant (IR) normoglycemic subjects. The implementation of a larger investigation with sufficient power is necessary to fully test our hypothesis and further explore these findings.

AdviserSusan Miller
Source TypeThesis
Publication Number1555104

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