Glycine supplementation to improve insulin sensitivity in humans

by Boni Epse Attobla, Marie-Hippolyte, M.S., THE UNIVERSITY OF ALABAMA AT BIRMINGHAM, 2014, 70 pages; 1555104

Abstract:

The main purpose of this pilot study was to investigate the insulin sensitizing effect of glycine as a dietary supplement in insulin resistant (IR) normoglycemic subjects (N= 10), and to determine significant changes in insulin sensitivity and lipid profile after four weeks of glycine supplementation. Descriptive statistics were used to describe the basic characteristics of the study population. A paired t-test was used to determine differences between insulin sensitivity and lipid profile pre- and post- intervention, considering the estimation of HOMA-IR and Matsuda- index scores. Results showed that glycine supplementation might improve triglyceride (TG) levels in European Americans; and low-density lipoprotein cholesterol (LDL-c) concentrations in women after a four-week of intervention. Although, this work reports interesting results, these findings did not provide sufficient evidence to demonstrate that glycine supplementation may improve insulin sensitivity and lipid profile in insulin-resistant (IR) normoglycemic subjects. The implementation of a larger investigation with sufficient power is necessary to fully test our hypothesis and further explore these findings.

AdviserSusan Miller
SchoolTHE UNIVERSITY OF ALABAMA AT BIRMINGHAM
Source TypeThesis
SubjectsNutrition
Publication Number1555104

About ProQuest Dissertations & Theses
With nearly 4 million records, the ProQuest Dissertations & Theses (PQDT) Global database is the most comprehensive collection of dissertations and theses in the world. It is the database of record for graduate research.

PQDT Global combines content from a range of the world's premier universities - from the Ivy League to the Russell Group. Of the nearly 4 million graduate works included in the database, ProQuest offers more than 2.5 million in full text formats. Of those, over 1.7 million are available in PDF format. More than 90,000 dissertations and theses are added to the database each year.

If you have questions, please feel free to visit the ProQuest Web site - http://www.proquest.com - or contact ProQuest Support.