Synthesis and characterization of copper releasing polymer nanoparticles
by Harris, Alesha N., M.S., UNIVERSITY OF NORTH TEXAS, 2011, 65 pages; 1504826

Abstract:

Polymeric nanoparticles were synthesized and loaded with Cu2+ to explore the therapeutic potential for catically active transition metal ions and complexes other than cisplatin. Two types of nanoparticles were synthesized to show the potential for polymer based vectors. Copper loading and release were characterized via inductively coupled plasma mass spectrometry (ICP MS), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), and elemental analysis. Results demonstrated that Cu could be loaded to the nano-sized carriers in an aqueous environment, and that the release was pH-dependent. The toxicity of these particles was measured in HeLa cells where significant toxicity was observed in vitro via dosing of high Cu-loaded nanoparticles. No significant toxicity was observed in cells dosed with Cu-free nanoparticles.
 
AdviserRobby A. Petros
SchoolUNIVERSITY OF NORTH TEXAS
SourceMAI/ 50-03, p. , Dec 2011
Source TypeThesis
SubjectsInorganic chemistry
Publication Number1504826
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