Osteoporosis is a bone disease prevalent among older women. The negative consequences of the disease range from fractured hips to diminished quality of life. Medication attributes contribute to the high rate of non-adherence. The study's purpose was to explore which four medication attributes (cost, dosing frequency, benefits, and adverse effects) were most important to post-menopausal women. A descriptive cross-sectional quantitative survey research design was given to a convenience sample of post-menopausal women. The survey included both a traditional and a conjoint method of analysis. Data analysis was conducted using SPSS 17.0. Independent variables were developed using constructs from the health belief model and the social cognitive theory, along with age and education. Decision-making was also incorporated into the study. Bivariate, multivariate, and conjoint analyses were conducted to test associations and determine which attributes the women considered most important. Study findings indicate that adverse effects of a medication were more important than benefits.