Cardiovascular disease (CVD) is the leading cause of death, disease, and disability among both men and women in the U.S. However, this problem is especially of concern for women and minority groups since women face a disproportionate risk for CVD. A cross-sectional survey was administered to investigate knowledge levels, health beliefs, personal risk factors, and health-promoting behaviors related to CVD among women working in an academic setting. Furthermore, the study examined sources from which women obtained information about CVD. The majority of sample included Caucasian (74%), highly educated women with a mean age of 49 years. Results indicated that general knowledge of CVD was high, yet risk factor knowledge was low. Majority of women were aware that CVD is the leading cause of death yet few women felt susceptible to CVD. Results from multiple regression showed that perceived barriers was the strongest predictor of health-promoting behaviors.