Athletes are continuously involved in certain performance enhancing programs such as weight lifting, speed and endurance development, and even nutrition to gain an edge over the competition; however, there is limited focus on the importance of reaction time. The ability to recognize, decide, and act on a certain stimulus is essential for almost all sports. Within this study, three choice reaction time tests were used to determine if there was a specificity of hand-eye and foot-eye reaction time for two open skilled sports (baseball, tennis). Twenty-four NCAA Division I athletes (13 baseball, 11 tennis) participated in this study. Each subject was required to perform one hand-eye and two foot-eye choice reaction time tests. Following this testing procedure, each subject's score was then averaged and combined with the other subjects to develop a mean for each sport. Statistical analysis was done using a one-way ANOVA to determine any significant differences ( p ≤ 0.05) between sports. As for the results, there was a significant difference between sports for the hand-eye reaction test (p ≤ 0.05). However, there were no significant differences found for either foot-eye reaction test (p ≥ 0.05). Based on these findings, it is suggested that there are differences in hand-eye reaction time between baseball and tennis. As a result, it seems important to implement specific training programs to benefit each of these athletes and improve their performance on the field.