The border between Mexico and the United States is a territory that has been conceptualized and constructed by the Mexican center and Chicano literatures. They base their perspectives on the contact the region has with the United States in terms of economic and cultural exchange. This tradition begins with the spatial delimitation of the border in 1848 with the Treaty of Guadalupe Hidalgo. In later years, the border was neglected by the Mexican center for its distance, except during the Mexican Revolution. However, the border region starts receiving great attention towards the end of the 20th Century when new forms of economic exchange between the two countries begin to develop. The region then undergoes a business boom that resulted in the resurgence and growth of the border culture. The cultural anthropologist Ernesto García Canclini, attempted to define the border culture by analyzing the usage of the English language in Tijuana. In both of his studies, Tijuana: la casa de todos (1989), and Culturas híbridas: Cómo entrar y salir de la modernidad (1992), García Canclini maintains that the border is a space of cultural hybridism. On the other hand, the dominant theories in the Chicano field define the region in metaphysical terms. For Gloria Anzaldúa, the border space is the Borderlands, a geographic area where the social and cultural paradigms are in constant conflict with the psychology of the individual. Considering these antecedents as our point of departure, this research focuses on the study of the border culture as multiple universes of cultural signs that come in contact with each other, rather than solely a hybrid culture. As established by Iury Lotman in La semiosfera (1996), a semiosphere is a semiotic space delimited by a border that translates information from other semiospheres. Thus, such concept becomes adequate in the analysis of the texts of Luis Humberto Crosthwaite's El gran preténder (1992), and Carlos Adolfo Gutierrez Vidal's Berlín 77 (y otros relatos) (2003). Ultimately, by defining the different cultural spaces in the border region as semiospheres, the level of contact between different cultures becomes evident, especially between the Mexican American/Chicana and the Mexican border cultures.