The purpose of this study was to explore the relationship between childhood maltreatment and juvenile homicide offending. Specifically, this study compared a sample of maltreated male juvenile homicide offenders (N = 51) with non-maltreated male juvenile homicide offenders (N = 364) among the following areas: familial dysfunction and disorganization, mental health issues, academic functioning, prior delinquency, substance abuse and homicide-related crime characteristics. Data was obtained from the following aggregate sources: Supervision Risk Classification Instrument (SRCI), the State Attorney's Recommendation form (SAR), the Predisposition Report (PR), and the Massachusetts Juveniles Screening Instrument 2 (MAYSI-2). Chi square and t-tests were then utilized to compare the two groups and preform analyses. Maltreated male juvenile homicide offenders significantly differed from non-maltreated male juvenile homicide offenders in terms of familial dysfunction and disorganization, academic functioning, prior delinquency and homicide-related crime characteristics. As a result of these significant differences, tailored prevention and treatment efforts were discussed.