The effects of neurotensin on the GABAergic system of the auditory cortex
by Lee, Mary, M.S., THE UNIVERSITY OF TEXAS AT DALLAS, 2010, 46 pages; 1485963

Abstract:

Neurotensin (NT) is an endogenous tridecapeptide (Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) that is distributed throughout the central and peripheral nervous system. In the brain, NT is found primarily in nerve cells, fibers and terminals [1] and in the periphery, NT is found in the intestinal mucosa [2] and cardiovascular tissue[3]. NT plays various roles including modulation of dopamine release, nociception, and hypothermia. It has also been reported that receptor NT has similar mechanisms to antipsychotic drugs. γ-Aminobutryic Acid (GABA) is an important neurotransmitter that regulates excitability in the nervous system and its function is consistently down regulated in schizophrenia[4]. For these reasons we studied the effects of NT on GABAergic transmission using patch-clamp to record GABA mediated inhibitory postsynaptic currents (IPSCs) from the auditory cortex.

 
AdviserMako Atzon
SchoolTHE UNIVERSITY OF TEXAS AT DALLAS
SourceMAI/ 49-01, p. , Sep 2010
Source TypeThesis
SubjectsNeurosciences
Publication Number1485963
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