This study examines the association between gender, craving and self-reported levels of depression and anxiety in a sample of 42 methamphetamine (MA) users in substance abuse treatment programs in Hilo, Hawai'i. This study employs the Beck Depression Inventory II (BDI-II), State Trait Anxiety Inventory (STAI Form Y), and the Desires for Speed Questionnaire (DSQ) to assess self reported levels of depression, anxiety, and craving in a sample of substance abusers engaged in treatment. It was hypothesized that female MA users would have higher scores on the BDI-II, STAI, and the DSQ than male MA users; and that regardless of gender, persons with higher scores on the DSQ would also have higher scores on the BDI-II and STAI. This study did not demonstrate the connection between MA craving intensity and gender. Nor, did this study find evidence to suggest that males and females experience different psychopathological syndromes associated with their MA use.