The transgender community encounters pervasive prejudice, discrimination, and violence, yet social science literature lacks research that focuses on reducing anti-transgender prejudice. The present study examined the effectiveness of three different interventions (i.e., emotional, fact-based, media) at decreasing negative attitudes toward transsexuals, correcting participants' beliefs in myths about transsexuality, and reducing their predicted discriminatory behaviors. Results revealed a significant decrease in participants' negative attitudes and beliefs in myths. However, no individual intervention proved more effective than the others at decreasing prejudice and myth endorsement. People of color displayed the strongest tendency to believe in myths about transsexuality. No significant pretest to posttest changes emerged for predicted discriminatory behaviors. Future directions for research include examining the effectiveness of a transgender discussion panel in reducing prejudice and investigating racial differences in transgender prejudice.