Historically, Paleoindian research has focused on big game hunting as the primary subsistence pattern. However, recent research suggests that Paleoindians in different regions of North America had a much more varied pattern of subsistence. Analysis of excavations at Jefferson II in northern New Hampshire supports this evidence for regional variation. This paper uses intrasite analysis, landscape and paleoenvironmental information to reconstruct the activities at Jefferson II and to show how it fits into the larger pattern of Paleoindian subsistence patterns in northeastern North America. Data from Jefferson II fits well with the growing body of research suggesting that Paleoindians in the Northeast were exploiting caribou as an important part of their mode of survival. In addition, Jefferson II underlines the importance of interpreting sites within a larger context of subsistence that incorporates local and regional landscapes and environments.