The purpose of this study was to perform a histological evaluation of new bone tissue formed in a canine mandible defect by bone transport osteogenesis and to evaluate the docking site. A bone segment of 3 cm in width was removed from the mandibles of 9 mature American foxhound dogs; in 5 of them the defect was left unrepaired; and in the other 4 dogs an additional segment of bone 1.5 cm mesial to the previously removed segment was created (transport disc). After a 4-5 day latency period, bone transport distraction was started at a rate of 0.5 mm/twice a day and continued until the transport disc reached the docking site on the opposite side of the defect. A period of 30 days was allowed for consolidation. For the histological evaluation the mandibles were resected en bloc, then hemi-sectioned, placed in formalin and processed for undecalcified histological sections. The blocks included the regenerated defect on the surgery side of the experimental group and the untreated defect on the control group along with the bone at the edges of the defect. There was a statistically significant increase in the bone volume in the segments that were treated with the BTRP device (43% of bone regeneration) compared to segments that were left untreated (6% bone regeneration). Evaluation of the docking site demonstrated that 50% of the sites showed union, and 50% were non-unions. The results of this study showed that formation of new bone was possible with the use of a novel bone device (BTRP). With respect to the docking site, achieving union still remains a problem and different techniques to induce union need to be tested.
|Adviser||Lynne A. Opperman|
|School||THE TEXAS A&M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER|
About ProQuest Dissertations & Theses
With nearly 4 million records, the ProQuest Dissertations & Theses (PQDT) Global database is the most comprehensive collection of dissertations and theses in the world. It is the database of record for graduate research.
PQDT Global combines content from a range of the world's premier universities - from the Ivy League to the Russell Group. Of the nearly 4 million graduate works included in the database, ProQuest offers more than 2.5 million in full text formats. Of those, over 1.7 million are available in PDF format. More than 90,000 dissertations and theses are added to the database each year.