The goals of this cross-cultural study were (1) to examine levels of role stressors and social support across cultures, (2) to investigate the relationships between role stressors and favorable attitudes and between social support and favorable attitudes, and (3) to examine the extent to which social support moderates the relationship between role stressors and favorable attitudes. The sample consisted of 1,796 employees in an Human Resources consulting firm across nine cultural regions. Mean scores on the main study variables (i.e., role stressors, coworker social support, supervisor social support, organizational social support, and favorable attitudes) significantly differed between cultural regions. Organizational social support buffered the stressor-favorable attitude relationship in USA and Canada, whereas a reverse buffering effect was found in Germanic Europe for both supervisor- and organizational-social support. Similarly, in Latin Europe, supervisor social support had a reverse buffering effect on the stressor-favorable attitude relationship. Implications of the study are discussed.