Exposure to alcohol during the brain growth spurt (first ten postnatal days in rats, comparable to the period of brain development during the human 3^rd trimester of pregnancy) results in impaired cognition and learning in adulthood. This impairment is accompanied by permanent structural changes in the hippocampus. Voluntary exercise improves performance on hippocampus-dependent learning and memory tasks and increases adult neurogenesis in the rat hippocampal dentate gyrus. The present study examined the effects of wheel running on dentate gyrus cell proliferation and neurogenesis in adolescent rats after neonatal binge-like alcohol exposure. During postnatal days 4-9, pups were intubated with alcohol in a binge like manner (two feedings two hours apart, 5.25g/kg/day), sham-intubated, or reared normally. On PD30-42 animals from all three postnatal treatments were further divided between two adolescent conditions: wheel running or inactive control. Animals were injected with BrdU (50mg/kg) every day between PD32-42 and perfused on PD42 or PD72. Cell proliferation and neurogenesis did not differ between postnatal treatment groups. Wheel running significantly increased cell proliferation and neurogenesis but only promoted survival of new cells in control rats. Although these results do not demonstrate an effect of postnatal alcohol exposure on adolescent neurogenesis, they do provide promising evidence that wheel running, through increasing proliferation and the number of newly generated neurons, may provide a basis to ameliorate learning impairments associated with alcohol exposure during the brain growth spurt.