Because multiple sclerosis (MS) has an impact on the identified patient and family members, it is vital for social work professionals to become competent in working with populations affected by MS. Social workers have the potential to become major providers in the coordination of services for persons affected by MS. The aim of the current study was to assess the impact of MS on perceived family functioning, specifically, family structure, perceived stress, and illness variables. Family functioning was measured by the Family Environment Scale, and was assessed through participants’ scores on 10 subscales, including: cohesion, expressiveness, conflict, independence, achievement orientation, intellectual-cultural orientation, active-recreational orientation, moral-religious emphasis, organization, and control. Findings suggested family functioning was impacted by the number of children in the family/household, the level of perceived stress, the course of MS, the amount of services utilized in relation to MS, the age of the respondent, and the gender of the individual. Findings have significant implications on services provided for families impacted by MS.