Colorectal cancer is the third most common cancer among African Americans in the United States. Colorectal cancer is curable if detected early; however, African-Americans are usually diagnosed when the disease is at an advanced stage. Over 50% of the eligible African-American population do not screen for the disease, leading to secondary and tertiary care and low survival rates. This study analyzed and determined the knowledge, attitudes and behaviors of African Americans toward colorectal cancer screening. The study utilized an anonymous semi-structured questionnaire, completed by 108 African Americans age 45 years and older in greater New Haven, CT. The results showed that the participants' overall knowledge, perceptions, and behaviors toward colorectal cancer screening were good, except that almost 53% of them perceived that they were not susceptible to colorectal cancer. The information from this study may be helpful in developing an appropriate method to change African Americans' behaviors toward colorectal cancer screening.