Linguistic research suggests that speakers represent syllable structure by a CV-frame. CVC syllables are more frequent than VCC ones. Further, the presence of VCC syllables in a language asymmetrically implies the presence of CVC syllables. These typological facts may reflect grammatical constraints. Alternatively, people's preferences may be due solely to their sensitivity to the statistical properties of sound combinations in their language. I demonstrate that participants in an auditory lexical decision task reject VCC nonwords faster than CVC nonwords, suggesting that the marked VCC syllables are dispreferred relative to CVC syllables. In a second experiment, I show that people are also sensitive to the distribution of these frames in the experiment. Findings indicate that syllable structure is represented at the phonological level, that individuals have preferences for certain syllables, and that these preferences can not be accounted for by the statistical properties of the stimuli.