Identification and characterization of a conserved isoform of the Drosophila Dorsal-related immunity factor, Dif.
by Mayo, Jason David, M.S., UNIVERSITY OF CALIFORNIA, SAN DIEGO, 2008, 52 pages; 1457300

Abstract:

The Dorsal-related immunity factor, Dif is a Drosophilid specific transcription factor that likely arose via gene duplication of Dorsal. An alternative splice variant was discovered for Dif based on bioinformatic analysis and conservation of Dorsal B homologs. This isoform, which I will term Dif B, is expressed in whole flies and S2 cells. The structure of Dif B has been characterized as a 987 amino acid protein that is identical to Dif up to the C-terminal end of the rel homology domain where it diverges completely. A hybrid Dif B cDNA was constructed for future use. Exon-specific RNAi suggests a possible inhibitory role for the Dif B isoform.
 
AdviserSteven A. Wasserman
SchoolUNIVERSITY OF CALIFORNIA, SAN DIEGO
SourceMAI/ 47-02, p. , Dec 2008
Source TypeThesis
SubjectsMolecular biology
Publication Number1457300
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