Chiral recognition and binding constant determination in monovalent and bivalent systems using electrospray ionization mass spectrometry
by Joshi, Manishkumar D., M.S., THE UNIVERSITY OF TEXAS AT ARLINGTON, 2008, 80 pages; 1456591

Abstract:

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization method which is capable of transferring weakly bound host-guest noncovalent complexes from the solution phase to the gas phase. This capability makes ESI-MS an ideal tool for the quantification of binding affinities of different host-guest noncovalent complexes.

There is a growing interest in using ESI-MS for chiral recognition studies. In this work ESI-MS was employed to investigate the binding affinities for cinchona alkaloid chiral selectors binding N-blocked leucine enantiomers, as well as for macrocyclic antibiotics binding a variety of derivatized and underivatized amino acids. The effect of multivalency on binding affinity was also evaluated. This ESI-MS method is very promising for the binding studies of different host-guest systems. Merits of this method are speed, sensitivity and low sample consumption.

 
AdvisersKevin A. Schug; Daniel W. Armstrong
SchoolTHE UNIVERSITY OF TEXAS AT ARLINGTON
SourceMAI/ 47-01, p. , Nov 2008
Source TypeThesis
SubjectsAnalytical chemistry
Publication Number1456591
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