Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology
by Bhatti, Amrinder Singh, M.S., FLORIDA ATLANTIC UNIVERSITY, 2008, 89 pages; 1456020

Abstract:

In this thesis I studied propensity for behavioral sensitization to nicotine in the LRHR phenotype and associated plasticity in the hippocampal mossy fiber morphology. I also investigated therapeutic effects of bupropion and a cannabinoid receptor antagonist on behavioral and morphological indices in adolescence and adulthood. Male rats were classified into high responders (HR) and low responders (LR) based on their locomotor response to a novel environment. LRHR animals underwent behavioral sensitization to nicotine and after one week of abstinence were challenged with a low dose of nicotine. HRs expressed behavioral sensitization to nicotine and showed an increase in hippocampal mossy fiber terminal field size. AM251 administration during abstinence reversed behavioral sensitization in HRs and bupropion only attenuated the locomotor response to naïve nicotine exposure. Therapeutic agents had differential effects on mossy fiber morphology dependent on phenotype and age.

 
AdviserCeylan Isgor
SchoolFLORIDA ATLANTIC UNIVERSITY
SourceMAI/ 46-06, p. , Sep 2008
Source TypeThesis
SubjectsMolecular biology; Neurosciences; Mental health
Publication Number1456020
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