The potential role of butyrophilin and xanthine oxidoreductase in controlling the amount and size of milk-fat droplets
by Jacob, Jaison, M.S., UNIVERSITY OF MARYLAND, COLLEGE PARK, 2008, 74 pages; 1454358

Abstract:

The secretion of fat droplets from mammary epithelial cells requires the expression of two major proteins, butyrophilin1A1 (BTN) and xanthine oxidoreductase (XOR). Ablation of the BTN or XOR gene in mice results in the accumulation of large fat droplets suggesting a reciprocal relationship between BTN/XOR concentration and milk-fat droplet size. We tested this hypothesis by correlating BTN/XOR concentrations in cow and mouse with their fat droplet size. The amount of BTN in mouse was 75 times less than in bovine samples. The size of fat droplets in mice was larger than in cow, but no correlation was found between fat-droplet size and the amount of BTN/XOR. Experimental reduction in fat-droplet size in mice did not change the concentration of BTN. We propose that a low amount of BTN is sufficient to mediate its role in milk-fat secretion and that it may have additional functions to its potential role as a structural protein.
 
AdviserIan H. Mather
SchoolUNIVERSITY OF MARYLAND, COLLEGE PARK
SourceMAI/ 47-01, p. , Oct 2008
Source TypeThesis
SubjectsCellular biology; Animal sciences
Publication Number1454358
Adobe PDF Access the complete dissertation:
 

» Find an electronic copy at your library.
  Use the link below to access a full citation record of this graduate work:
  http://gateway.proquest.com/openurl%3furl_ver=Z39.88-2004%26res_dat=xri:pqdiss%26rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation%26rft_dat=xri:pqdiss:1454358
  If your library subscribes to the ProQuest Dissertations & Theses (PQDT) database, you may be entitled to a free electronic version of this graduate work. If not, you will have the option to purchase one, and access a 24 page preview for free (if available).

About ProQuest Dissertations & Theses
With over 2.3 million records, the ProQuest Dissertations & Theses (PQDT) database is the most comprehensive collection of dissertations and theses in the world. It is the database of record for graduate research.

The database includes citations of graduate works ranging from the first U.S. dissertation, accepted in 1861, to those accepted as recently as last semester. Of the 2.3 million graduate works included in the database, ProQuest offers more than 1.9 million in full text formats. Of those, over 860,000 are available in PDF format. More than 60,000 dissertations and theses are added to the database each year.

If you have questions, please feel free to visit the ProQuest Web site - http://www.proquest.com - or call ProQuest Hotline Customer Support at 1-800-521-3042.