Reproductive factors and risk of B-cell non-Hodgkin's lymphomas among women in Los Angeles
by Lu, Yani, M.S., UNIVERSITY OF SOUTHERN CALIFORNIA, 2008, 39 pages; 1454056

Abstract:

Study aim. Reproductive patterns have been inconsistently linked to NHL risk. The aim of this study is to identify if these factors affect B-cell NHL risk among women. Methods. We conducted a population-based case-control study in Los Angeles County. A total of 555 histologically confirmed B-cell NHL patients and 555 individually matched control subjects were included. Conditional logistic regression was used to evaluate these associations. Results. Reproductive history factors such as gravidity, parity, and outcome of first pregnancy were not associated with B-cell NHL risk overall or any NHL subtype. A modest association was observed for use of lactation suppressants (OR=0.78, 95% CI=0.56-1.08). The use of diethylstilbestrol (DES) during pregnancy increased the risk of B-cell NHL (OR=2.10, 95% CI=0.71-6.23). Conclusion. Reproductive factors were not associated with the risk of B-cell NHL overall or any subtype. Future studies with greater numbers of NHL subtypes are needed to confirm our study results.

 
AdviserLeslie Bernstein
SchoolUNIVERSITY OF SOUTHERN CALIFORNIA
SourceMAI/ 46-06, p. , Sep 2008
Source TypeThesis
SubjectsWomen's studies; Epidemiology
Publication Number1454056
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