This study used data from the homicides in Chicago 1965-1995 dataset (N=9,340) to examine the relationship between the use of certain types of weapons in criminal homicides by gender, race, age, victim-offender relationship, motive, location, and changes over time. Differential association and sex-role theory were utilized to argue why gender differences would occur in type of weapon used in a homicide. Subculture of violence theory was used to emphasize that the place where the homicide occurs, the relationship between the victim and offender, motive of the offender, and the remaining variables affects the type of weapon used to kill. Significant relationships were found for all bivariate analyses performed. The type of weapon used to kill differs most by sex of offender, resulting in a moderately strong association. The type of weapon used to kill differs least by age of offender and although statistically significant, the association between the two is very weak.