Group A p21-activated kinases in radial neuronal migration
by Halberstadt, Ari I., M.S., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, 2007, 52 pages; 1442318

Abstract:

The p21-activated kinases (PAKs) are downstream effectors of signal transducers including Rac and Cdc42. PAKs are involved in cytoskeletal rearrangements during cell migration, mitosis, dendritic spine formation, and neurite outgrowth. While the general expression pattern of PAKs in the brain was known, possible effects of PAK kinase activity on early brain development had not been described. I studied the expression pattern of activated PAKs 1-3 by immunoblotting and immunofluorescence in embryonic mouse brains and the effect of disruption of PAK activity during development on radial migration and early neuronal remodeling at the cortical plate. Active PAKs were observed in progenitor cells, in which they were coexpressed with PAK1 phosphorylated at T212, and in the developing cortical plate. Disruption of PAK activity did not affect radial cell distribution in the neocortex or neurite number in early neurons in the cortical plate.
 
AdviserPatricia Maness
SchoolTHE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
SourceMAI/ 45-04, p. , Jun 2007
Source TypeThesis
SubjectsNeurosciences
Publication Number1442318
Adobe PDF Access the complete dissertation:
 

» Find an electronic copy at your library.
  Use the link below to access a full citation record of this graduate work:
  http://gateway.proquest.com/openurl%3furl_ver=Z39.88-2004%26res_dat=xri:pqdiss%26rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation%26rft_dat=xri:pqdiss:1442318
  If your library subscribes to the ProQuest Dissertations & Theses (PQDT) database, you may be entitled to a free electronic version of this graduate work. If not, you will have the option to purchase one, and access a 24 page preview for free (if available).

About ProQuest Dissertations & Theses
With over 2.3 million records, the ProQuest Dissertations & Theses (PQDT) database is the most comprehensive collection of dissertations and theses in the world. It is the database of record for graduate research.

The database includes citations of graduate works ranging from the first U.S. dissertation, accepted in 1861, to those accepted as recently as last semester. Of the 2.3 million graduate works included in the database, ProQuest offers more than 1.9 million in full text formats. Of those, over 860,000 are available in PDF format. More than 60,000 dissertations and theses are added to the database each year.

If you have questions, please feel free to visit the ProQuest Web site - http://www.proquest.com - or call ProQuest Hotline Customer Support at 1-800-521-3042.